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    Browsing by Subject sub-chronic toxicity

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    • Article

    • Acute and sub-chronic oral toxicities of DA.Amlodepon HVD hard capsule in experimental animals

      • Authors: Pham Thi Van Anh, Nguyen Van Dam; Nguyen Van Dat (2021)

    • Assessment of toxicities of DA.AMLODEPON HVD hard capsule on experimental animals. The acute toxicity of DA.AMLODEPON HVD was assessed on Swiss mice according to World Health Organization Guidance, and LD50 determination according to the method of Litchfield – Wilcoxon. The sub-chronic toxicity study of DA.AMLODEPON HVD at two doses (0.42 g/kg/day and 1.26g/kg/day) was conducted in rats for four consecutive weeks. After administration, general conditions and the body weight of rats were evaluated. Blood samples were collected for analyzing serum parameters before treatment (T0), second week (T1), and fourth week (T2).
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    • magazine

    • Evaluation of sub-chronic toxicity of TD.MV hard capsule in experimental rats

      • Authors: Trinh Vinh Quang; Nguyen Thi Huong Lien; Nguyen Thi Hong Van (2020)

    • The method used in this study follows the guidance of the World Health Organization and Organization for Economic Co-operation and Development. Rats were treated at both dosage of 0.18 grams and 0.54 grams per kilogram body weight for a period of 90 consecutive days. Results showed that TD.MV hard capsules caused no significant dose-related changes in general health status and body weight. We also found no notable changes in hematological parameters, no renal and hepatic damage through both biochemical tests and histological images. In conclusion, TD.MV hard capsules at two doses, 0.18 and 0.54 g/kg/day, did not cause sub-chronic toxicity in rats.
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    • Article

    • Sub-chronic oral toxicity study of "Kien Nao Dan" tablets in experimental animal

      • Authors: Le Thanh Xuan, Le Thi Nhat Ngoc (2021)

    • The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological change or sign of toxicity. The result of the hematological and biological parameters after administration of PTD tablets showed no change. ...
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    • Article

    • Sub-chronic oral toxicity study of "Phong Thap Dan" tablets in experimental animal

      • Authors: Trinh Thi Thuy Hong, Le Thanh Xuan; Tran Quang Minh (2021)

    • “Kien nao dan” (KND) tablet is composed of 13 traditional medicines that may has preventive and effective treatment of cerebral ischemia. However, there are no scientific reports of its toxicological properties which guarantee of the safety its usage treatment. Therefore, the aim of this study was to investigate the sub-chronic toxicity of KND tablet on rats through oral administration. The sub-chronic toxicity was evaluated by the recommendation of WHO in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no beha...
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    • magazine

    • Toxicity evaluation of acute and sub-chronic oral toxicity of Hamo NK hard capsule in experimental animals

      • Authors: Dang Thi Thu Hien; Nguyen Trong Thong; Pham Thuy Phuong (2020)

    • Hamo NK hard capsule is composed of dry extracts formulation of herbal medicine which had shown good properties for effective treatment of dyslipidemia. However, there are no scientific report of its toxicological properties which would guarantee its safe usage as a potent treatment of dyslipidemia. Therefore, the present study was to investigate acute and sub-chronic toxicity of Hamo NK on mice and rats through oral administration. Acute toxicity study was performed in Swiss mice at tolerable ascending doses in mice and followed up to 7 days